Issue 17, 2009

Polyamideamino acids: a new class of RNAligands

Abstract

This communication introduces a new class of promising RNAligands, named polyamideamino acids (PAA), which are able to bind a targeted bulged stem-loopRNA fragment (HIV-1 TAR RNA) with micromolar affinities and with specificity comparative to dsDNA and tRNA; both the affinity and the specificity of PAA for TAR depend on their length and on the nature of the amino acid residues.

Graphical abstract: Polyamide amino acids: a new class of RNAligands

Supplementary files

Article information

Article type
Communication
Submitted
02 Sep 2008
Accepted
11 Feb 2009
First published
06 Mar 2009

Chem. Commun., 2009, 2302-2304

Polyamide amino acids: a new class of RNAligands

V. Bonnard, S. Azoulay, A. Di Giorgio and N. Patino, Chem. Commun., 2009, 2302 DOI: 10.1039/B815324H

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