Issue 3, 2009

From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy

Abstract

Based on the incorporation of commercially available N-Fmoc-furylalanine, a new method for peptide labeling is proposed, relying on the selective oxidative transformation of the furan moiety into a reactive aldehyde and subsequent reductive amination.

Graphical abstract: From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy

Supplementary files

Article information

Article type
Communication
Submitted
06 Oct 2008
Accepted
11 Nov 2008
First published
01 Dec 2008

Chem. Commun., 2009, 340-342

From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy

A. Deceuninck and A. Madder, Chem. Commun., 2009, 340 DOI: 10.1039/B817447D

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