Issue 12, 2009

First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant

Abstract

The first total synthesis of the potent antioxidantantiostatin A1 is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.

Graphical abstract: First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2008
Accepted
16 Jan 2009
First published
18 Feb 2009

Chem. Commun., 2009, 1464-1466

First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant

C. Alayrac, D. Schollmeyer and B. Witulski, Chem. Commun., 2009, 1464 DOI: 10.1039/B820291E

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