Issue 11, 2009
From the journal:

Chemical Communications

Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA†

Daniel Oves-Costales,a   Lijiang Songa  and  Gregory L. Challis*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: g.l.challis@warwick.ac.uk
Fax: +44 (0)247 652 4112
Tel: +44 (0)247 657 4024

Abstract

AsbA catalyses the highly enantioselective desymmetrisation of citric acidvia ATP-dependent condensation with spermidine, as well as the condensation of citric acid with several spermidine analogues and the condensation of the citric acid analogue tricarballylic acid with spermidine, suggesting that it may be a useful biocatalyst for asymmetric synthesis.

Graphical abstract: Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA

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Article information

DOI
https://doi.org/10.1039/B823147H
Article type
Communication
Submitted
24 Dec 2008
Accepted
28 Jan 2009
First published
16 Feb 2009

Chem. Commun., 2009, 1389-1391

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Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA

D. Oves-Costales, L. Song and G. L. Challis, Chem. Commun., 2009, 1389 DOI: 10.1039/B823147H

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