Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells

Saad Shabaan; Lalla A. Ba; Muhammad Abbas; Torsten Burkholz; Annika Denkert; André Gohr; Ludger A. Wessjohann; Florenz Sasse; Wolfgang Weber; Claus Jacob

doi:10.1039/B823149D

Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells†

Saad Shabaan,^a Lalla A. Ba,^a Muhammad Abbas,^ab Torsten Burkholz,^a Annika Denkert,^b André Gohr,^b Ludger A. Wessjohann,^b Florenz Sasse,^c Wolfgang Weber^d and Claus Jacob*^a

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^a Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany
E-mail: c.jacob@mx.uni-saarland.de
Fax: +49 681 302 3464
Tel: +49 681 302 3129

^b Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany

^c Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany

^d Department of Experimental Medicine, Biochemistry I, University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany

Abstract

Multicomponent Passerini and Ugi reactions enable the fast and efficient synthesis of redox-active multifunctional selenium and tellurium compounds, of which some show considerable cytotoxicity against specific cancer cells.

Chemical Communications

Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells†

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Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells

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