Study on acetylcholinesteraseinhibition induced by endogenous neurotoxin with an enzyme–semiconductor photoelectrochemical system

Wei Zhu; Ya-Rui An; Xiao-Min Luo; Fei Wang; Jiao-Hong Zheng; Lin-Lin Tang; Qing-Jiang Wang; Zhong-Hai Zhang; Wen Zhang; Li-Tong Jin

doi:10.1039/B900623K

Study on acetylcholinesteraseinhibition induced by endogenous neurotoxin with an enzyme–semiconductor photoelectrochemical system†

Wei Zhu,^a Ya-Rui An,^a Xiao-Min Luo,^b Fei Wang,^b Jiao-Hong Zheng,^a Lin-Lin Tang,^a Qing-Jiang Wang,^a Zhong-Hai Zhang,^a Wen Zhang*^a and Li-Tong Jin*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, East China Normal University, 3663 Zhongshan Rd.(N), P.R. China
E-mail: wzhang@chem.ecnu.edu.cn
Fax: +86 21 6223 2627
Tel: +86 21 6223 3509

^b Center for Drug Discovery and Design and State Key Laboratory of Drug Research, Shanghai Institute of Meteria Medica and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, P.R. China

Abstract

The integration of Au-doped TiO₂ nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE–Au–TiO₂ hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChEinhibition induced by endogenous neurotoxin.

Chemical Communications

Study on acetylcholinesteraseinhibition induced by endogenous neurotoxin with an enzyme–semiconductor photoelectrochemical system†

Abstract

Supplementary files

Additions and corrections

Article information

Download Citation

Permissions

Study on acetylcholinesteraseinhibition induced by endogenous neurotoxin with an enzyme–semiconductor photoelectrochemical system

Social activity

Search articles by author

Spotlight

Advertisements