Issue 17, 2009
From the journal:

Chemical Communications

Synthesis of 2-fluoroalkylbenzimidazoles via copper(i)-catalyzed tandem reactions†

Jiangtao Zhu,a   Haibo Xie,a   Zixian Chen,ab   Shan Lia  and  Yongming Wu*a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 LingLing Road, Shanghai 200032, P. R. China
E-mail: ymwu@mail.sioc.ac.cn
Fax: (+86) 21-54925192

b Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China

Abstract

Preparation of 2-fluoroalkylbenzimidazoles from N-aryl trifluoroacetimidoyl (or bromodifluoroacetimidoyl) chlorides and primary amines has been achieved via copper(I)-catalyzed tandem reactions.

Graphical abstract: Synthesis of 2-fluoroalkylbenzimidazoles via copper(i)-catalyzed tandem reactions

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Article information

DOI
https://doi.org/10.1039/B900984A
Article type
Communication
Submitted
16 Jan 2009
Accepted
12 Feb 2009
First published
09 Mar 2009

Chem. Commun., 2009, 2338-2340

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Synthesis of 2-fluoroalkylbenzimidazoles via copper(I)-catalyzed tandem reactions

J. Zhu, H. Xie, Z. Chen, S. Li and Y. Wu, Chem. Commun., 2009, 2338 DOI: 10.1039/B900984A

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