Issue 16, 2009

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

Abstract

A range of enantiomerically pure (R)- and (S)-configured chiral amines has been prepared in excellent e.e. (99%) by combining a transaminase enzyme with an amino acid oxidase and catalytic quantities of pyruvate.

Graphical abstract: Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2009
Accepted
05 Mar 2009
First published
16 Mar 2009

Chem. Commun., 2009, 2127-2129

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

M. D. Truppo, N. J. Turner and J. D. Rozzell, Chem. Commun., 2009, 2127 DOI: 10.1039/B902995H

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