Issue 30, 2009
From the journal:

Chemical Communications

Tyrosine-67 in cytochrome c is a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition†

Tianlei Ying,‡a   Zhong-Hua Wang,‡a   Ying-Wu Lin,a   Jin Xie,a   Xiangshi Tan*a  and  Zhong-Xian Huang*a  

* Corresponding authors

a Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
E-mail: zxhuang@fudan.edu.cn, xstan@fudan.edu.cn
Fax: +86-21-65641740
Tel: +86-21-65643973

Abstract

We found that cyt c Y67H and Y67R variants represent a state which resembles the conformational intermediate state in cyt c with high peroxidase activity; and also the hydrogen bond network around Tyr67 is associated with the conformational transition of cyt c; these suggest that the hydrogen bond network around Tyr67 is essential in maintaining the cyt c functioning not only as an electron transfer protein but also probably as a trigger in apoptosis.

Graphical abstract: Tyrosine-67 in cytochrome c is a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B904347K
Article type
Communication
Submitted
03 Mar 2009
Accepted
15 Jun 2009
First published
29 Jun 2009

Chem. Commun., 2009, 4512-4514

Permissions

Request permissions

Tyrosine-67 in cytochrome c is a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition

T. Ying, Z. Wang, Y. Lin, J. Xie, X. Tan and Z. Huang, Chem. Commun., 2009, 4512 DOI: 10.1039/B904347K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements