Issue 26, 2009

Unconventional oxazole formation from isocyanides

Abstract

The coupling of an acyl chloride with an isocyanide affords 2,5-disubstituted oxazoles under mild basic conditions instead of 4,5-disubstituted derivatives when using Schöllkopf conditions (butyllithium); this reaction constitutes a remarkable example of a base-induced chemoselective process in isocyanide chemistry.

Graphical abstract: Unconventional oxazole formation from isocyanides

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2009
Accepted
07 May 2009
First published
20 May 2009

Chem. Commun., 2009, 3907-3909

Unconventional oxazole formation from isocyanides

A. dos Santos, L. El Kaïm, L. Grimaud and C. Ronsseray, Chem. Commun., 2009, 3907 DOI: 10.1039/B904699B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements