Issue 26, 2009

Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters

Abstract

Highly enantioselective α-hydroxylation of cyclic and acyclic 1,3-ketoesters can be achieved with up to 98% ee using a dicationic palladium(II) catalyst and dimethyldioxirane as oxidant.

Graphical abstract: Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters

Supplementary files

Article information

Article type
Communication
Submitted
08 Apr 2009
Accepted
01 May 2009
First published
22 May 2009

Chem. Commun., 2009, 3925-3927

Palladium-catalysed enantioselective α-hydroxylation of β-ketoesters

A. M. R. Smith, D. Billen and K. K. (. Hii, Chem. Commun., 2009, 3925 DOI: 10.1039/B907151B

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