Issue 5, 2010
From the journal:

Lab on a Chip

Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor

Yang Yang,ab   Hanqiao Zhang,a   Junjie Zhu,c   Gaoyan Wang,d   Tzuen-Rong Tzeng,d   Xiangchun Xuan,c   Kama Huangb  and  Pingshan Wang*a  

* Corresponding authors

a Department of Electrical and Computer Engineering, Clemson University, Clemson, South Carolina, USA
E-mail: yang6@clemson.edu, pwang@clemson.edu
Fax: +1 864-656-5910
Tel: +1 864-656-2117

b School of Electronics and Information Engineering, Sichuan University, Chengdu, Sichuan, China
Fax: +86 28-85408779
Tel: +86 28-85408779

c Department of Mechanical Engineering, Clemson University, Clemson, South Carolina, USA

d Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA

Abstract

We propose and demonstrate a simple, ultra sensitive radio frequency (RF) sensor to detect a single yeast cell and distinguish its viability in a microfluidic channel. On-chip interference is used to cancel background probing signals to improve sensor sensitivity. Individual viable and nonviable yeast cells (∼ 5.83 ± 0.85 μm in diameter) are measured with clear sensing and identification of these cells.

Graphical abstract: Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor

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Article information

DOI
https://doi.org/10.1039/B921502F
Article type
Communication
Submitted
15 Oct 2009
Accepted
12 Jan 2010
First published
26 Jan 2010

Lab Chip, 2010,10, 553-555

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Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor

Y. Yang, H. Zhang, J. Zhu, G. Wang, T. Tzeng, X. Xuan, K. Huang and P. Wang, Lab Chip, 2010, 10, 553 DOI: 10.1039/B921502F

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