Oxygen-independent photonuclease activity of a new iron(II) complex

Bernardo de Souza; Fernando R. Xavier; Rosely A. Peralta; Adailton J. Bortoluzzi; Gilmar Conte; Hugo Gallardo; Franciele L. Fischer; Giselle Bussi; Hernán Terenzi; Ademir Neves

doi:10.1039/B922560A

Oxygen-independent photonuclease activity of a new iron(ii) complex†

Bernardo de Souza,^a Fernando R. Xavier,^a Rosely A. Peralta,^a Adailton J. Bortoluzzi,^a Gilmar Conte,^a Hugo Gallardo,^a Franciele L. Fischer,^b Giselle Bussi,^b Hernán Terenzi*^b and Ademir Neves*^a

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^a Departamento de Química, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil
E-mail: ademir@qmc.ufsc.br
Tel: +55 48 3721 8844

^b Departamento de Bioquímica, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil

Abstract

A new iron(II) complex was synthesized and its photonuclease activity against plasmid DNA was evaluated. After kinetic experiments a k_cat of 18.86 ± 2.9 h⁻¹ was obtained, one of the highest nuclease activities of synthetic metallonucleases, selectively activated by 365 nm UV light.

Chemical Communications

Oxygen-independent photonuclease activity of a new iron(ii) complex†

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Oxygen-independent photonuclease activity of a new iron(II) complex

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