Issue 24, 2010

Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another

Abstract

Mature fibrils prepared from apo-α-lactalbumin spontaneously refold from one polymorph to another as a result of a mild alteration in solution temperature and salinity. This discovery changes the very concept of the extraordinary stability of amyloid fibrils and presages a new approach for potentially regulating the biological activity of fibrils and their associated toxicity.

Graphical abstract: Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another

Supplementary files

Article information

Article type
Communication
Submitted
18 Dec 2009
Accepted
15 Jan 2010
First published
27 Jan 2010

Chem. Commun., 2010,46, 4249-4251

Amyloid fibrils are “alive”: spontaneous refolding from one polymorph to another

D. Kurouski, W. Lauro and I. K. Lednev, Chem. Commun., 2010, 46, 4249 DOI: 10.1039/B926758A

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