Issue 1, 2009

DNA functionalized gold nanoparticles for bioanalysis

Abstract

Gold nanoparticles (Au NPs) have become one of the most interesting sensing materials because of their unique size- and shape-dependent optical properties, high extinction coefficients, and super-quenching capability. Au NPs that are bioconjugated with DNA (DNA-Au NPs) have been demonstrated for selective and sensitive detection of analytes such as mercury(II) ions, platelet-derived growth factor (PDGF), and adenosine triphosphate (ATP). This review focuses on approaches using DNA-Au NPs for colorimetric, fluorescent, and scattering detection of biopolymers and small solutes. We highlight the important roles that the size and concentration of Au NPs, the length and sequence of DNA, the nature of the capping agents, and the ionic strength and pH of solution play in determining the specificity and sensitivity of the nanosensors for the analytes. The advantages and disadvantages of different detection methods for sensing of interesting analytes using DNA-Au NPs will be discussed.

Graphical abstract: DNA functionalized gold nanoparticles for bioanalysis

Article information

Article type
Review Article
Submitted
18 May 2009
Accepted
05 Aug 2009
First published
07 Sep 2009

Anal. Methods, 2009,1, 14-24

DNA functionalized gold nanoparticles for bioanalysis

Y. Lin, C. Liu and H. Chang, Anal. Methods, 2009, 1, 14 DOI: 10.1039/B9AY00036D

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