Issue 10, 2010
From the journal:

Organic & Biomolecular Chemistry

A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite†

Tongqiang Wang,a   Yuanyuan Hua  and  Songlin Zhang*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry. Chemical Engineering and Materials Science of Soochow University, Suzhou, People's Republic of China
E-mail: zhangsl@suda.edu.cn

Abstract

The widely available carbonyl compounds react with Grignard reagents in the presence of diethyl phosphite to give the corresponding olefins in good to excellent yields: A range of conjugated dienes, terminal olefins, multisubstituted-alkenes and conjugated enynes could be readily obtained by the method in mild conditions.

Graphical abstract: A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite

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Article information

DOI
https://doi.org/10.1039/C001931C
Article type
Communication
Submitted
12 Feb 2010
Accepted
23 Mar 2010
First published
07 Apr 2010

Org. Biomol. Chem., 2010,8, 2312-2315

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A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite

T. Wang, Y. Hu and S. Zhang, Org. Biomol. Chem., 2010, 8, 2312 DOI: 10.1039/C001931C

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