Issue 14, 2010
From the journal:

Organic & Biomolecular Chemistry

Supramolecular hydrogels inspired by collagen for tissue engineering†

Yuehan Hu,a   Huaimin Wang,ac   Jingyu Wang,ac   Sibing Wang,b   Wang Liao,d   Yonggang Yang,b   Yongjun Zhang,d   Deling Kong*a  and  Zhimou Yang*ac  

* Corresponding authors

a Key Laboratory of Bioactive Materials, Ministry of Education, College of Chemistry, Nankai University, Tianjin, P. R. China
E-mail: kongdeling@nankai.edu.cn

b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, P. R. China

c Department of Biochemistry and Molecular Biology, College of Life Sciences, College of Chemistry, Nankai University, Tianjin, P. R. China
E-mail: yangzm@nankai.edu.cn

d Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, P. R. China
Fax: +86-22-23498775
Tel: +86-22-23502875

Abstract

Supramolecular hydrogels are promising biomaterials for cell culture in 2-D and 3-D environments. Inspired by the chemical structure of collagen, which bears the repeating tripeptide of glycine-Xaa-4R-hydroxyproline (GXO; Xaa is any one of the natural amino acids), we designed and synthesized a small library of supramolecular hydrogelators (a total of 6). We found that four of the hydrogels were suitable for NIH 3T3 cell culture in the 2-D environments. Gel 2, the best hydrogel, has properties that are similar to those of collagen for 3T3 cell culture. These findings not only provide more supramolecular hydrogel candidates for tissue engineering, but also offer a new strategy for designing biomaterials that mimic nature.

Graphical abstract: Supramolecular hydrogels inspired by collagen for tissue engineering

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Article information

DOI
https://doi.org/10.1039/C002609C
Article type
Paper
Submitted
10 Feb 2010
Accepted
10 May 2010
First published
26 May 2010

Org. Biomol. Chem., 2010,8, 3267-3271

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Supramolecular hydrogels inspired by collagen for tissue engineering

Y. Hu, H. Wang, J. Wang, S. Wang, W. Liao, Y. Yang, Y. Zhang, D. Kong and Z. Yang, Org. Biomol. Chem., 2010, 8, 3267 DOI: 10.1039/C002609C

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