Issue 13, 2010

Efforts toward rapid construction of the cortistatin A carbocyclic core viaenyne-enemetathesis

Abstract

Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted SN2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry.

Graphical abstract: Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2010
Accepted
04 May 2010
First published
24 May 2010

Org. Biomol. Chem., 2010,8, 2915-2917

Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

C. Baumgartner, S. Ma, Q. Liu and B. M. Stoltz, Org. Biomol. Chem., 2010, 8, 2915 DOI: 10.1039/C004275G

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