Issue 1, 2011
From the journal:

Chemical Communications

An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance†‡

Xuli Feng,a   Libing Liu,*a   Xinrui Duana  and  Shu Wang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
E-mail: wangshu@iccas.ac.cn, liulibing@iccas.ac.cn
Fax: +86 10 6263 6680
Tel: +86 10 6263 6680

Abstract

Synthetic riboswitch containing aptamer is constructed in E. coli to regulate the expression of β-lactamase through small molecule–aptamer interactions, which sharply reduces the antibiotic resistance of the engineered bacteria.

Graphical abstract: An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance

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Article information

DOI
https://doi.org/10.1039/C0CC00980F
Article type
Communication
Submitted
16 Apr 2010
Accepted
02 Jun 2010
First published
30 Jun 2010

Chem. Commun., 2011,47, 173-175

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An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance

X. Feng, L. Liu, X. Duan and S. Wang, Chem. Commun., 2011, 47, 173 DOI: 10.1039/C0CC00980F

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