Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

Giorgia Oliviero; Jussara Amato; Nicola Borbone; Stefano D'Errico; Aldo Galeone; Luciano Mayol; Shozeb Haider; Olujide Olubiyi; Bart Hoorelbeke; Jan Balzarini; Gennaro Piccialli

doi:10.1039/C0CC02866E

Tetra-end-linked oligonucleotides forming DNAG-quadruplexes: a new class of aptamers showing anti-HIV activity†

Giorgia Oliviero,^a Jussara Amato,^a Nicola Borbone,*^a Stefano D'Errico,^a Aldo Galeone,*^a Luciano Mayol,^a Shozeb Haider,^b Olujide Olubiyi,^b Bart Hoorelbeke,^c Jan Balzarini^c and Gennaro Piccialli^a

Author affiliations

* Corresponding authors

^a Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Napoli, Italy
E-mail: galeone@unina.it, borbone@unina.it

^b CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK

^c Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Abstract

The biophysical and biological properties of unprecedented anti-HIV aptamers are presented. The most active aptamer (1L) shows a significant affinity to the HIV protein gp120.

Chemical Communications

Tetra-end-linked oligonucleotides forming DNAG-quadruplexes: a new class of aptamers showing anti-HIV activity†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

Social activity

Search articles by author

Spotlight

Advertisements