Issue 3, 2011

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Abstract

A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse model, and was selected for further pre-clinical evaluation as a potential treatment for hepatitis C viral infection.

Graphical abstract: The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Supplementary files

Article information

Article type
Concise Article
Submitted
01 Nov 2010
Accepted
03 Dec 2010
First published
20 Dec 2010

Med. Chem. Commun., 2011,2, 185-189

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

D. C. Pryde, T. Tran, P. Jones, G. C. Parsons, G. Bish, F. M. Adam, M. C. Smith, D. S. Middleton, N. N. Smith, F. Calo, D. Hay, M. Paradowski, K. J. W. Proctor, T. Parkinson, C. Laxton, D. N. A. Fox, N. J. Horscroft, G. Ciaramella, H. M. Jones, J. Duckworth, N. Benson, A. Harrison and R. Webster, Med. Chem. Commun., 2011, 2, 185 DOI: 10.1039/C0MD00197J

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