Monolithic flow microreactors improve fine chemicals synthesis

Abstract

This contribution reviews the preparation, main characteristics and advantages of macroporous monolithic microreactors for the synthesis of fine chemicals by continuous flow catalytic processes. The review focuses on different types of monolith (polymers, polymer/glass, silica, zeolites) exhibiting macropores of typically 2 to 10 μm, a large pore volume (1–2 mL g⁻¹) and a high surface area (>300 m² g⁻¹) that can be readily functionalized by a variety of active moieties. With respect to traditional batch and packed-bed reactors, monolithic reactors allow easier process implementation, higher productivity and improved selectivity.