Issue 20, 2010

Asymmetric transfer hydrogenation of ketones catalyzed by rhodium complexes containing amino acid triazole ligands

Abstract

Active and selective catalysts for the asymmetric reduction of ketones, under transfer hydrogenation conditions, were obtained by combining [RhCl2Cp*]2, with a series of L-amino acid thioamide ligands functionalized with 1,2,3-triazoles. The obtained secondary alcohol products were formed with up to 93% ee.

Graphical abstract: Asymmetric transfer hydrogenation of ketones catalyzed by rhodium complexes containing amino acid triazole ligands

Supplementary files

Article information

Article type
Communication
Submitted
08 Jul 2010
Accepted
06 Aug 2010
First published
19 Aug 2010

Org. Biomol. Chem., 2010,8, 4536-4539

Asymmetric transfer hydrogenation of ketones catalyzed by rhodium complexes containing amino acid triazole ligands

F. Tinnis and H. Adolfsson, Org. Biomol. Chem., 2010, 8, 4536 DOI: 10.1039/C0OB00400F

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