The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

Wenbing Hu; Qun Luo; Kui Wu; Xianchan Li; Fuyi Wang; Yi Chen; Xiaoyan Ma; Jianping Wang; Jianan Liu; Shaoxiang Xiong; Peter J. Sadler

doi:10.1039/C1CC11627D

The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin†

Wenbing Hu,^a Qun Luo,^a Kui Wu,^a Xianchan Li,^a Fuyi Wang,*^a Yi Chen,^a Xiaoyan Ma,^b Jianping Wang,^b Jianan Liu,^a Shaoxiang Xiong^a and Peter J. Sadler*^c

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* Corresponding authors

^a CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
E-mail: fuyi.wang@iccas.ac.cn
Fax: +86 10-6252-9069

^b State Key Laboratory of Molecular Reaction Dynamics, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China

^c Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
E-mail: p.j.sadler@warwick.ac.uk
Fax: +44 (0)24-765 23818

Abstract

Cisplatin, cis-[Pt(Cl₂(NH₃)₂], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

Chemical Communications

The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin†

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The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

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