Issue 26, 2011

On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines

Abstract

The synthetic utility of S-mesitylsulfinimines for the synthesis of chiral amines and aziridines was examined through their reactions with Grignard reagents, with the ylides derived from trimethylsulfonium iodide and S-allyl-tetrahydrothiophenium bromide and through an aza-Darzens manifold, affording convenient access to a diverse range of highly substituted chiral amines and aziridines in high yields and excellent stereoselectivities.

Graphical abstract: On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines

Supplementary files

Article information

Article type
Communication
Submitted
01 Apr 2011
Accepted
12 May 2011
First published
31 May 2011

Chem. Commun., 2011,47, 7491-7493

On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines

C. Roe, T. M. Solá, L. Sasraku-Neequaye, H. Hobbs, I. Churcher, D. MacPherson and R. A. Stockman, Chem. Commun., 2011, 47, 7491 DOI: 10.1039/C1CC11870F

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