Issue 30, 2011

Palladium-catalyzed haloallylation of aromatic ynolethers with allyl chlorides: a highly regio- and stereoselective approach to (1E)-α-chloroenol ethers

Abstract

Described herein is a Pd-catalyzed haloallylation of aromatic ynol ethers and allyl chlorides, allowing facile access to (1E)-α-chloroenol ethers in a highly regio- and stereoselective manner. The synthetic utility of this method is demonstrated well by the synthesis of the stereodefined multisubstituted enol ethers and α-allylated carbonyl compounds.

Graphical abstract: Palladium-catalyzed haloallylation of aromatic ynol ethers with allyl chlorides: a highly regio- and stereoselective approach to (1E)-α-chloroenol ethers

Supplementary files

Article information

Article type
Communication
Submitted
09 Jun 2011
Accepted
20 Jun 2011
First published
30 Jun 2011

Chem. Commun., 2011,47, 8682-8684

Palladium-catalyzed haloallylation of aromatic ynol ethers with allyl chlorides: a highly regio- and stereoselective approach to (1E)-α-chloroenol ethers

H. Cai, Z. Yuan, W. Zhu and G. Zhu, Chem. Commun., 2011, 47, 8682 DOI: 10.1039/C1CC13424H

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