Issue 39, 2011
From the journal:

Chemical Communications

Site-selective DNAhydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate†

Ming-Qi Wang,a   Jun-Liang Liu,a   Jing-Yi Wang,a   Da-Wei Zhang,b   Ji Zhang,a   Frank Streckenbach,c   Zhuo Tang,*c   Hong-Hui Lin,*b   Yan Liu,d   Yu-Fen Zhaod  and  Xiao-Qi Yu*a  

* Corresponding authors

a Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu, P. R. China
E-mail: xqyu@scu.edu.cn
Fax: +86 28 85415886

b Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan, P. R. China

c Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, P. R. China

d College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China

Abstract

A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.

Graphical abstract: Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate

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Article information

DOI
https://doi.org/10.1039/C1CC14185F
Article type
Communication
Submitted
12 Jul 2011
Accepted
11 Aug 2011
First published
07 Sep 2011

Chem. Commun., 2011,47, 11059-11061

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Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate

M. Wang, J. Liu, J. Wang, D. Zhang, J. Zhang, F. Streckenbach, Z. Tang, H. Lin, Y. Liu, Y. Zhao and X. Yu, Chem. Commun., 2011, 47, 11059 DOI: 10.1039/C1CC14185F

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