Issue 2, 2012

17 erhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application

Abstract

Cyanocobalamin (B12) offers a biocompatible scaffold for CO-releasing 17-electron dicarbonyl complexes based on the cis-trans-[ReII(CO)2Br2]0 core. A Co–C[triple bond, length as m-dash]N–Re conjugate is produced in a short time and high yield from the reaction of [Et4N]2[ReIIBr4(CO)2] (ReCORM-1) with B12. The B12-ReII(CO)2 derivatives show a number of features which make them pharmaceutically acceptable CO-releasing molecules (CORMs). These cobalamin conjugates are characterized by an improved stability in aqueous aerobic media over the metal complex alone, and afford effective therapeutic protection against ischemia-reperfusion injury in cultured cardiomyocytes. The non-toxicity (at μM concentrations) of the resulting metal fragment after CO release is attributed to the oxidation of the metal and formation in solution of the ReO4 anion, which is among the least toxic of all of the rare inorganic compounds. Theoretical and experimental studies aimed at elucidating the aqueous chemistry of ReCORM-1 are also described.

Graphical abstract: 17 e−rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application

Supplementary files

Article information

Article type
Paper
Submitted
13 Apr 2011
Accepted
22 Jul 2011
First published
01 Sep 2011

Dalton Trans., 2012,41, 370-378

17 erhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application

F. Zobi, O. Blacque, R. A. Jacobs, M. C. Schaub and A. Yu. Bogdanova, Dalton Trans., 2012, 41, 370 DOI: 10.1039/C1DT10649J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements