Issue 5, 2012

Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions

Abstract

Nonracemic ethano-bridged Tröger bases are prepared using CuTC-catalyzed decompositions of diazo compounds. Excellent levels of diastereo- and enantio-control (dr and ee up to 12 : 1 and 95% respectively) are now obtained with aryl diazoketone precursors.

Graphical abstract: Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions

Supplementary files

Article information

Article type
Paper
Submitted
18 Oct 2011
Accepted
24 Oct 2011
First published
01 Dec 2011

Org. Biomol. Chem., 2012,10, 966-969

Asymmetric synthesis of ethano-Tröger bases using CuTC-catalyzed diazo decomposition reactions

A. Sharma, C. Besnard, L. Guénée and J. Lacour, Org. Biomol. Chem., 2012, 10, 966 DOI: 10.1039/C1OB06751F

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