Issue 5, 2012
From the journal:

RSC Advances

Microwave-assisted synthesis of hydropyridines and study of the DPPH-scavenging activity†

Julio Montes-Avila,a   Francisco Delgado-Vargas,ab   Sylvia P. Díaz-Camachoac  and  Ignacio A. Rivero*d  

* Corresponding authors

a Universidad Autónoma de Sinaloa, Facultad de Ciencias Químico Biológicas, Boulevard de las Américas s/n, Culiacán, Sinaloa, CP, México

b Maestría en Ciencia y Tecnología de Alimentos, Boulevard de las Américas s/n, Culiacán, Sinaloa, CP, México

c Maestría en Ciencias Biomédicas, Boulevard de las Américas s/n, Culiacán, Sinaloa, CP, México

d Instituto Tecnológico de Tijuana, Centro de Graduados e Investigación en Química, Apartado Postal 1166, Tijuana, B. C., México
E-mail: irivero@tectijuana.mx

Abstract

A series of hydropyridines (HP's) were synthesized using dimedones, ethyl acetoacetate, ammonium acetate and appropriate aldehydes under solvent-free conditions and microwave-irradiation through Hantzsch reaction. All the synthesized HP's were tested in vitro for the 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and structure–activity relationship was discussed; only 12 out of the 36 HP's showed antioxidant activity. Polyhydroquinolines (PHQ's) were the most active compounds among the studied HP's, they were characterized by the lack of an ester-like structure substituent at carbon 5.

Graphical abstract: Microwave-assisted synthesis of hydropyridines and study of the DPPH-scavenging activity

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Article information

DOI
https://doi.org/10.1039/C1RA01135A
Article type
Paper
Submitted
18 Nov 2011
Accepted
18 Nov 2011
First published
04 Jan 2012

RSC Adv., 2012,2, 1827-1834

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Microwave-assisted synthesis of hydropyridines and study of the DPPH-scavenging activity

J. Montes-Avila, F. Delgado-Vargas, S. P. Díaz-Camacho and I. A. Rivero, RSC Adv., 2012, 2, 1827 DOI: 10.1039/C1RA01135A

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