Issue 30, 2012
From the journal:

Chemical Communications

Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions†

Jing Wang,a   Jiande Gu*ab  and  Jerzy Leszczynski*a  

* Corresponding authors

a Interdisciplinary Nanotoxicity Center, Department of Chemistry and Biochemistry, Jackson State University, Jackson, USA
E-mail: jerzy@icnanotox.org

b Drug Design & Discovery Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, P. R. China
E-mail: jiande@icnanotox.org

Abstract

Investigation of the hydrolysis of dinucleoside-arsenate-deoxyguanylyl-3′,5′-deoxyguanosine (dGAsdG−) reveals that base-stacking in DNA increases the resistance of As–DNA towards hydrolysis. Base-stacking raises the activation energy of hydrolysis. Hydrolysis of As–DNA is found to be endothermic. The hydrolysis stability of As–DNA should be higher than that estimated based on arsenate diester models.

Graphical abstract: Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

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Article information

DOI
https://doi.org/10.1039/C2CC16600C
Article type
Communication
Submitted
24 Oct 2011
Accepted
16 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3626-3628

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Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

J. Wang, J. Gu and J. Leszczynski, Chem. Commun., 2012, 48, 3626 DOI: 10.1039/C2CC16600C

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