Issue 41, 2012
From the journal:

Chemical Communications

Enantiospecific kinking of DNA by a partially intercalating metal complex†

Anna Reymera  and  Bengt Nordén*a  

* Corresponding authors

a Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden
E-mail: reymer@chalmers.se, norden@chalmers.se
Fax: +46 31 772 3858
Tel: +46 31 772 3041

Abstract

Opposite enantiomers of [Ru(phenanthroline)3]2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins.

Graphical abstract: Enantiospecific kinking of DNA by a partially intercalating metal complex

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Article information

DOI
https://doi.org/10.1039/C2CC31176C
Article type
Communication
Submitted
16 Feb 2012
Accepted
20 Mar 2012
First published
21 Mar 2012

Chem. Commun., 2012,48, 4941-4943

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Enantiospecific kinking of DNA by a partially intercalating metal complex

A. Reymer and B. Nordén, Chem. Commun., 2012, 48, 4941 DOI: 10.1039/C2CC31176C

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