Issue 95, 2012

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

Abstract

Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.

Graphical abstract: Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

Supplementary files

Article information

Article type
Communication
Submitted
11 Sep 2012
Accepted
15 Oct 2012
First published
16 Oct 2012

Chem. Commun., 2012,48, 11623-11625

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

C. Gabbiani, F. Scaletti, L. Massai, E. Michelucci, M. A. Cinellu and L. Messori, Chem. Commun., 2012, 48, 11623 DOI: 10.1039/C2CC36610J

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