Issue 48, 2012
From the journal:

Journal of Materials Chemistry

Enhanced protein-mediated binding between oligonucleotide–gold nanoparticle composites and cell surfaces: co-transport of proteins and composites†

Yu Jin Kim,a   Sang-Mi Ryou,b   Sudeok Kim,c   Ji-Hyun Yeom,b   Min Su Han,*ac   Kangseok Lee*b  and  Maeng-Je Seong*ad  

* Corresponding authors

a Institute of Innovative Functional Imaging, Chung-Ang University, Seoul 156-756, Korea

b Department of Life Science, Chung-Ang University, Seoul 156-756, Korea
E-mail: kangseok@cau.ac.kr

c Department of Chemistry, Chung-Ang University, Seoul 156-756, Korea
E-mail: mshan@cau.ac.kr

d Department of Physics, Chung-Ang University, Seoul 156-756, Korea
E-mail: mseong@cau.ac.kr
Fax: +82 2-825-4988

Abstract

The measurement of the binding force between a cell membrane and an oligonucleotide-functionalized, gold-coated tip using atomic force microscope force spectroscopy showed enhanced binding forces due to the presence of proteins in the buffer. The cellular uptake of oligonucleotide–gold nanoparticle composites was also enhanced when the composites were coated with serum proteins. Confocal microscopy image analysis of fluorescently labeled serum proteins and the oligonucleotides of the composites revealed co-transport of proteins and the composites.

Graphical abstract: Enhanced protein-mediated binding between oligonucleotide–gold nanoparticle composites and cell surfaces: co-transport of proteins and composites

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Article information

DOI
https://doi.org/10.1039/C2JM34047J
Article type
Paper
Submitted
22 Jun 2012
Accepted
04 Oct 2012
First published
17 Oct 2012

J. Mater. Chem., 2012,22, 25036-25041

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Enhanced protein-mediated binding between oligonucleotide–gold nanoparticle composites and cell surfaces: co-transport of proteins and composites

Y. J. Kim, S. Ryou, S. Kim, J. Yeom, M. S. Han, K. Lee and M. Seong, J. Mater. Chem., 2012, 22, 25036 DOI: 10.1039/C2JM34047J

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