Standing surface acoustic wave (SSAW) based multichannel cell sorting

Xiaoyun Ding; Sz-Chin Steven Lin; Michael Ian Lapsley; Sixing Li; Xiang Guo; Chung Yu Chan; I-Kao Chiang; Lin Wang; J. Philip McCoy; Tony Jun Huang

doi:10.1039/C2LC40751E

Standing surface acoustic wave (SSAW) based multichannel cell sorting

Xiaoyun Ding,^a Sz-Chin Steven Lin,^a Michael Ian Lapsley,^a Sixing Li,^ab Xiang Guo,^a Chung Yu Chan,^a I-Kao Chiang,^a Lin Wang,^c J. Philip McCoy^d and Tony Jun Huang*^ab

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* Corresponding authors

^a Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA
E-mail: junhuang@psu.edu
Fax: 814-865-9974
Tel: 814-863-4209

^b Cell and Developmental Biology Program, The Pennsylvania State University, University Park, PA 16802, USA

^c Ascent Bio-Nano Technologies Inc., State College, PA 16801, USA

^d National Heart, Lung, and Blood Institute at NIH, Bethesda, MD 20892, USA

Abstract

We introduce a novel microfluidic device for cell sorting in continuous flow using tunable standing surface acoustic waves. This method allows individual cells to be precisely directed into five different outlet channels in a single step. It is versatile, simple, label-free, non-invasive, and highly controllable.

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Standing surface acoustic wave (SSAW) based multichannel cell sorting

Abstract

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