Issue 4, 2012

A second generation MRI contrast agent for imaging zinc ionsin vivo

Abstract

A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.

Graphical abstract: A second generation MRI contrast agent for imaging zinc ions in vivo

Supplementary files

Article information

Article type
Concise Article
Submitted
06 Dec 2011
Accepted
23 Jan 2012
First published
07 Mar 2012

Med. Chem. Commun., 2012,3, 480-483

A second generation MRI contrast agent for imaging zinc ions in vivo

L. M. De León-Rodríguez, A. J. M. Lubag, J. A. López, G. Andreu-de-Riquer, J. C. Alvarado-Monzón and A. D. Sherry, Med. Chem. Commun., 2012, 3, 480 DOI: 10.1039/C2MD00301E

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