Issue 1, 2013

Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligand

Abstract

The interactions of long telomeric DNAs, which mimic telomeres in living cells, with a macrocyclic hexaoxazole ligand L2H2-6OTD (2) were investigated by means of electrophoresis mobility shift assay, circular dichroism (CD) titration analysis, and DNA melting measurements. Our results indicate that G4 structure in long telomeric DNAs was mainly induced to take anti-parallel topology upon interaction with L2H2-6OTD (2). The overall higher-order G4 organizational structure of the long telomeric DNAs was suggested to be of beads-on-a-string type.

Graphical abstract: Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligand

Supplementary files

Article information

Article type
Concise Article
Submitted
08 Aug 2012
Accepted
19 Oct 2012
First published
07 Nov 2012

Med. Chem. Commun., 2013,4, 260-264

Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligand

K. Iida, G. Tsubouchi, T. Nakamura, S. Majima, H. Seimiya and K. Nagasawa, Med. Chem. Commun., 2013, 4, 260 DOI: 10.1039/C2MD20234D

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