Issue 8, 2012
From the journal:

Organic & Biomolecular Chemistry

N-heterocyclic carbene-mediated hydroacylation–Sonogashira/Heck/Suzuki coupling in a single pot: A new cascade reaction†

M. Sreenivasulu,ab   K. Siva Kumar,a   P. Rajender Kumar,a   K. B. Chandrasekharb  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad, India

b Department of Chemistry, Jawaharlal Nehru Technological University of Anantapur, Anantapur, Andhra Pradesh, India

c Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, Andhra Pradesh, India
E-mail: manojitpal@rediffmail.com

Abstract

A dually NHC-catalyzed reaction cascade comprising an initial hydroacylation of an activated ketone and subsequent Sonogashira/Heck/Suzuki coupling in the same pot is reported. The reaction mechanism and scope of the methodology is presented.

Graphical abstract: N-heterocyclic carbene-mediated hydroacylation–Sonogashira/Heck/Suzuki coupling in a single pot: A new cascade reaction

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Article information

DOI
https://doi.org/10.1039/C2OB06950D
Article type
Paper
Submitted
19 Nov 2011
Accepted
23 Nov 2011
First published
23 Nov 2011

Org. Biomol. Chem., 2012,10, 1670-1679

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N-heterocyclic carbene-mediated hydroacylation–Sonogashira/Heck/Suzuki coupling in a single pot: A new cascade reaction

M. Sreenivasulu, K. S. Kumar, P. R. Kumar, K. B. Chandrasekhar and M. Pal, Org. Biomol. Chem., 2012, 10, 1670 DOI: 10.1039/C2OB06950D

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