Issue 11, 2012

Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams

Abstract

The first tertiary amine-catalyzed multicomponent tandem Strecker–allylic-alkylation (SAA) reaction has been developed, which provides a facile access to functionalized α-amino nitriles, which could be readily converted into α-methylene-γ-butyrolactams.

Graphical abstract: Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams

Supplementary files

Article information

Article type
Communication
Submitted
16 Dec 2011
Accepted
17 Jan 2012
First published
10 Feb 2012

Org. Biomol. Chem., 2012,10, 2214-2217

Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams

F. Pan, J. Chen, Z. Zhuang, Y. Fang, S. X. Zhang and W. Liao, Org. Biomol. Chem., 2012, 10, 2214 DOI: 10.1039/C2OB07112F

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