Issue 38, 2013

Development of a chemical probe for identifying protein targets of α-oxoaldehydes

Abstract

The development of a chemical probe for identifying the protein targets of reactive electrophilic α-oxoaldehydes such as methylglyoxal is presented. The probe is evaluated against methylglyoxal using human serum albumin as well as using living cells and lysates.

Graphical abstract: Development of a chemical probe for identifying protein targets of α-oxoaldehydes

Supplementary files

Article information

Article type
Communication
Submitted
08 Feb 2013
Accepted
24 Mar 2013
First published
25 Mar 2013

Chem. Commun., 2013,49, 4012-4014

Development of a chemical probe for identifying protein targets of α-oxoaldehydes

C. Sibbersen, J. Palmfeldt, J. Hansen, N. Gregersen, K. A. Jørgensen and M. Johannsen, Chem. Commun., 2013, 49, 4012 DOI: 10.1039/C3CC41099D

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