Issue 69, 2013

Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

Abstract

An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosylation sites that were substituted with S-linked glycans.

Graphical abstract: Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

Supplementary files

Article information

Article type
Communication
Submitted
09 May 2013
Accepted
26 Jun 2013
First published
28 Jun 2013

Chem. Commun., 2013,49, 7608-7610

Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

A. Novoa, S. Barluenga, C. Serba and N. Winssinger, Chem. Commun., 2013, 49, 7608 DOI: 10.1039/C3CC43458C

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