Issue 80, 2013
From the journal:

Chemical Communications

Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy†

Nirmalya Bag,a   Ashraf Ali,b   Virander Singh Chauhan,b   Thorsten Wohland*a  and  Aseem Mishra*b  

* Corresponding authors

a Departments of Biological Sciences and Chemistry and NUS Centre for Bio-Imaging Sciences (CBIS), National University of Singapore, Singapore
E-mail: twohland@nus.edu.sg
Fax: +65-6776 7882
Tel: +65-6516 1248

b Malaria Research Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
E-mail: aseem@icgeb.res.in

Abstract

Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity.

Graphical abstract: Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy

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Article information

DOI
https://doi.org/10.1039/C3CC44880K
Article type
Communication
Submitted
29 Jun 2013
Accepted
05 Aug 2013
First published
29 Aug 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 9155-9157

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Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy

N. Bag, A. Ali, V. S. Chauhan, T. Wohland and A. Mishra, Chem. Commun., 2013, 49, 9155 DOI: 10.1039/C3CC44880K

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