Issue 87, 2013

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

Abstract

Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

Graphical abstract: Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2013
Accepted
20 Sep 2013
First published
23 Sep 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 10245-10247

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

J. A. Fuentes, I. Carpenter, N. Kann and M. L. Clarke, Chem. Commun., 2013, 49, 10245 DOI: 10.1039/C3CC45545A

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