Issue 14, 2014

Protein conformation as a regulator of cell–matrix adhesion

Abstract

The dynamic regulation of cell–matrix adhesion is essential for tissue homeostasis and architecture, and thus numerous pathologies are linked to altered cell–extracellular matrix (ECM) interaction and ECM scaffold. The molecular machinery involved in cell–matrix adhesion is complex and involves both sensory and matrix-remodelling functions. In this review, we focus on how protein conformation controls the organization and dynamics of cell–matrix adhesion. The conformational changes in various adhesion machinery components are described, including examples from ECM as well as cytoplasmic proteins. The discussed mechanisms involved in the regulation of protein conformation include mechanical stress, post-translational modifications and allosteric ligand-binding. We emphasize the potential role of intrinsically disordered protein regions in these processes and discuss the role of protein networks and co-operative protein interactions in the formation and consolidation of cell–matrix adhesion and extracellular scaffolds.

Graphical abstract: Protein conformation as a regulator of cell–matrix adhesion

Article information

Article type
Perspective
Submitted
19 Nov 2013
Accepted
13 Jan 2014
First published
13 Jan 2014

Phys. Chem. Chem. Phys., 2014,16, 6342-6357

Author version available

Protein conformation as a regulator of cell–matrix adhesion

V. P. Hytönen and B. Wehrle-Haller, Phys. Chem. Chem. Phys., 2014, 16, 6342 DOI: 10.1039/C3CP54884H

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