Multifunctional lipid-coated polymer nanogels crosslinked by photo-triggered Michael-type addition

Abstract

Novel, multifunctional lipid-coated polymer nanogels crosslinked by photo-triggered Michael-type addition were prepared via the use of liposome templates. The photo-sensitive gelation and temporal control of the crosslinking reaction were confirmed by oscillatory rheology experiments of bulk hydrogels, and the production of nanogels was confirmed via dynamic light scattering and transmission electron microscopy. The surface functionality of the lipid-coated nanogels was demonstrated by surface modification with a reactive fluorescent dye. These multifunctional lipid-coated nanogels, given the mild preparation conditions, ease of size control, and versatility of the chemical linkages used as cross-links, have significant potential for use in polymeric nanoparticulate drug delivery systems.