Issue 12, 2014

“On water” highly atom economical and rapid synthesis of a novel class of 3-hydroxy-2-oxindole scaffolds under a catalyst-free and column chromatography-free protocol at room temperature

Abstract

An “on water” highly atom economical and rapid protocol has been developed for the synthesis of a novel class of 3-(2-pyrazolin-5-one) substituted, 3-hydroxy-2-oxindole scaffolds under catalyst-free and column chromatography-free conditions at rt. The generality of the method has been demonstrated by screening a series of isatin electrophiles as well as 2-pyrazolin-5-one derivatives. The developed method is a good example of green synthesis in which straightforward synthesis of a medicinally important 3-hydroxy-2-oxindole framework is executed by employing very mild, simple and handy procedures from readily available starting materials.

Graphical abstract: “On water” highly atom economical and rapid synthesis of a novel class of 3-hydroxy-2-oxindole scaffolds under a catalyst-free and column chromatography-free protocol at room temperature

Supplementary files

Article information

Article type
Communication
Submitted
12 Nov 2013
Accepted
12 Dec 2013
First published
18 Dec 2013

RSC Adv., 2014,4, 6019-6026

“On water” highly atom economical and rapid synthesis of a novel class of 3-hydroxy-2-oxindole scaffolds under a catalyst-free and column chromatography-free protocol at room temperature

P. B. Thakur and H. M. Meshram, RSC Adv., 2014, 4, 6019 DOI: 10.1039/C3RA46613B

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