Issue 45, 2014
From the journal:

Chemical Communications

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect†

Bogdan Draghici,a   Daniela Vullo,b   Suleyman Akocak,a   Ellen A. Walker,a   Claudiu T. Supuran*b  and  Marc A. Ilies*a  

* Corresponding authors

a Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA-19140, USA
E-mail: mailies@temple.edu
Fax: +1 215-707-5620
Tel: +1 215-707-1749

b NEUROFARBA Department, Pharmaceutical Sciences Section, Universita degli Studi di Firenze, Polo Scientifico, Via Ugo Schiff no. 6, 50019 Sesto Fiorentino, Florence, Italy
E-mail: claudiu.supuran@unifi.it
Fax: +39-055-4573385
Tel: +39-055-4573005

Abstract

A series of ethylene bis-imidazoles was synthesized via a novel microwave-mediated synthesis. Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ.

Graphical abstract: Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

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Article information

DOI
https://doi.org/10.1039/C4CC02346C
Article type
Communication
Submitted
29 Mar 2014
Accepted
14 Apr 2014
First published
15 Apr 2014

Chem. Commun., 2014,50, 5980-5983

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Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

B. Draghici, D. Vullo, S. Akocak, E. A. Walker, C. T. Supuran and M. A. Ilies, Chem. Commun., 2014, 50, 5980 DOI: 10.1039/C4CC02346C

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