Issue 80, 2014

Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

Abstract

Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu2+ selective fluorescent sensor in living cells. This derivative is one of the rare examples of reversible fluorescent chemosensors for Cu2+ which uses a boronic acid group for a binding site. Moreover, the adduct BNP–Cu2+ displays a fluorescence enhancement with fructose. The uptake of this novel compound in HeLa cancer cells was imaged using confocal fluorescence microscopy techniques including two-photon fluorescence lifetime imaging microscopy.

Graphical abstract: Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

Supplementary files

Article information

Article type
Communication
Submitted
07 May 2014
Accepted
03 Jun 2014
First published
04 Jun 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 11806-11809

Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(II)

M. Li, H. Ge, R. L. Arrowsmith, V. Mirabello, S. W. Botchway, W. Zhu, S. I. Pascu and T. D. James, Chem. Commun., 2014, 50, 11806 DOI: 10.1039/C4CC03453H

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