Issue 100, 2014
From the journal:

Chemical Communications

A click-and-release approach to CO prodrugs†‡

Danzhu Wang,a   Emilie Viennois,b   Kaili Ji,a   Krishna Damera, ORCID logo a   Alexander Draganov,a   Yueqing Zheng,a   Chaofeng Dai,a   Didier Merlinb  and  Binghe Wang*a  

* Corresponding authors

a Department of Chemistry, Georgia State University, Atlanta, Georgia
E-mail: wang@gsu.edu

b Department of Biology, Georgia State University, Atlanta, Georgia

Abstract

Carbon monoxide belongs to the family of signaling molecules and has been shown to possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing CO-based therapeutics. Herein we report a “click and release” CO-prodrug approach, which allows the release of CO under physiological conditions without the need for light irradiation. The system releases CO in a triggered and controllable manner and possesses the potential of tunable release rates.

Graphical abstract: A click-and-release approach to CO prodrugs

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Article information

DOI
https://doi.org/10.1039/C4CC07748B
Article type
Communication
Submitted
03 Oct 2014
Accepted
31 Oct 2014
First published
31 Oct 2014

Chem. Commun., 2014,50, 15890-15893

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A click-and-release approach to CO prodrugs

D. Wang, E. Viennois, K. Ji, K. Damera, A. Draganov, Y. Zheng, C. Dai, D. Merlin and B. Wang, Chem. Commun., 2014, 50, 15890 DOI: 10.1039/C4CC07748B

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