Issue 24, 2015

Associative chemosensing by fluorescent macrocycle–dye complexes – a versatile enzyme assay platform beyond indicator displacement

Abstract

A label-free in situ method to monitor reactions in real time by using fluorescent supramolecular chemosensors based on cucurbit[8]uril is presented. It allows sensing of enzymatic activity, inhibitor and activator screening, and analyte detection with unprecedented versatility and high sensitivity.

Graphical abstract: Associative chemosensing by fluorescent macrocycle–dye complexes – a versatile enzyme assay platform beyond indicator displacement

Supplementary files

Article information

Article type
Communication
Submitted
22 Dec 2014
Accepted
15 Jan 2015
First published
15 Jan 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 4977-4980

Author version available

Associative chemosensing by fluorescent macrocycle–dye complexes – a versatile enzyme assay platform beyond indicator displacement

F. Biedermann, D. Hathazi and W. M. Nau, Chem. Commun., 2015, 51, 4977 DOI: 10.1039/C4CC10227D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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